PHE885 CAR-T Therapy in Adult Participants With Relapsed and Refractory Multiple Myeloma
- Trial number:
- NCT05172596
- Trial phase:
- 2
- Study type:
- Targeted therapy
- Overall status:
- Recruiting
Study start date
Scientific title
Summary
≥18 years of age at the time of informed consent form (ICF) signatureAdult patients with relapsed and refractory multiple myeloma who have received at least 3 prior lines of therapy including an IMiD (e.g., lenalidomide or pomalidomide), a proteasome inhibitor (e.g., bortezomib, carfilzomib), and an approved anti-CD38 antibody (e.g., daratumumab, isatuximab), and have documented evidence of disease progression (IMWG criteria) Must be refractory to the last treatment regimen (defined as progressive disease on or within 60 days measured from last dose of last regimen). Measurable disease at enrollment as defined by the protocol Eastern Cooperative Oncology Group (ECOG) performance status that is either 0 or 1 at screening Must have a leukapheresis material of non-mobilized cells accepted for manufacturing