Novartis

www.novartis.com.sg

About

Novartis is reimagining medicine to improve and extend people’s lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. In our quest to find new medicines, we consistently rank among the world’s top companies investing in research and development. Novartis products reach nearly 800 million people globally and we are finding innovative ways to expand access to our latest treatments. About 110,000 people of more than 140 nationalities work at Novartis around the world. To learn more about Novartis in Singapore, visit https://www.novartis.com.sg

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Novartis

20 Pasir Panjang Road #10-25/28, Mapletree Business City (West Tower), Singapore 117439

+65 6722 6010

Key Trials

3 trials shown

Novartis

Official trial

Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

24 February 2021

This is a phase Ib/II open label study. The escalation part will characterize the safety and tolerability of JDQ443 single agent and JDQ443 in combination with the other study treatments (TNO155 and spartalizumab) in advanced solid tumor patients. After the determination of the maximum tolerated dose / recommended dose for a particular treatment arm, dose expansion will assess the anti-tumor activity and further assess the safety, tolerability, and PK/PD of each regimen at the maximum tolerated dose / recommended dose.

Trial number:: NCT04699188

Study type:: targeted, biomarker

Trial phase:: 1, 2

Overall status:: Recruiting

Novartis

Official trial

Safety and Preliminary Efficacy of JBH492 Monotherapy in Patients With Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin's Lymphoma (NHL)

7 September 2020

The purpose of the First-In-Human study is to assess safety, tolerability, pharmacokinetics (PK), immunogenicity and preliminary efficacy of JBH492 as single agent.

Trial number:: NCT04240704

Study type:: chemotherapy, targeted

Trial phase:: 1

Overall status:: Recruiting

Novartis

Official trial

Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors

26 May 2017

The purpose of this first in human (FIH) trial is to characterize the safety and tolerability of the SHP2 inhibitor TNO155 alone and in combination with EGF816 (nazartinib) and identify a recommended dose for future studies in adult patients with advanced solid tumors in selected indications.

Trial number:: NCT03114319

Study type:: targeted, biomarker

Trial phase:: 1

Overall status:: Recruiting