Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
- Trial number:
- NCT04700124
- Trial phase:
- 3
- Study type:
- Immunotherapy, Targeted therapy
- Overall status:
- Recruiting
Study start date
April, 2021
Scientific title
A Phase 3, Randomized, Open-label Study to Evaluate Perioperative Enfortumab Vedotin Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Gemcitabine and Cisplatin in Cisplatin-eligible Participants With Muscle-invasive Bladder Cancer (KEYNOTE-B15 / EV-304)
Summary
The purpose of this study is to assess the antitumor efficacy and safety of perioperative enfortumab vedotin (EV) plus pembrolizumab and radical cystectomy (RC) + pelvic lymph node dissection (PLND) compared with the current standard of care (neoadjuvant chemotherapy [gemcitabine plus cisplatin] and RC + PLND) for participants with MIBC who are cisplatin-eligible. The primary hypothesis is perioperative EV and pembrolizumab and RC + PLND (Arm A) will achieve superior event free survival (EFS) compared with neoadjuvant gemcitabine + cisplatin and RC + PLND (Arm B).
Have a histologically confirmed diagnosis of urothelial carcinoma (UC) / muscle invasive bladder cancer (MIBC) (T2-T4aN0M0 or T1-T4aN1M0) with predominant (≥50%) urothelial histology.Have clinically non-metastatic bladder cancer (N≤1 M0) determined by imaging (computed tomography (CT) or magnetic resonance imaging (MRI) of the chest/abdomen/pelvis Be deemed eligible for Radical Cystectomy (RC) + Pelvic Lymph Node Dissection (PLND) Have Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Have adequate organ function.
Study design
Primary purpose:
Treatment, Allocation:
Randomized, Intervention model:
Parallel Assignment, Masking:
None (Open Label), Masking description:
Open label,
Conditions
Bladder Cancer
Other study ID numbers
3475-B15; MK-3475-B15; KEYNOTE-B15; EV-304; jRCT2041210011; PHRR221021-005086; 2020-003106-31
Choose trial site (217)
St. Joseph Heritage Healthcare ( Site 0035)
955 W Imperial Hwy, Fullerton, CA 92835, USA
UF Health ( Site 0031)
1515 SW Archer Rd, Gainesville, FL 32608, USA
Icahn School of Medicine at Mount Sinai ( Site 0011)
1 Gustave L. Levy Pl, New York, NY 10029, USA
White Plains Hospital ( Site 0039)
41 E Post Rd, White Plains, NY 10601, USA
MidLantic Urology ( Site 0002)
Bala Cynwyd, PA 19004, USA
Saint Francis Cancer Center ( Site 0008)
104 Innovation Dr, Greenville, SC 29607, USA
The University of Tennessee Medical Center ( Site 0034)
1924 Alcoa Hwy, Knoxville, TN 37920, USA
UT Southwestern Medical Center ( Site 0003)
5323 Harry Hines Blvd, Dallas, TX 75390, USA
Urology of San Antonio ( Site 0020)
7909 Fredericksburg Rd Suite 110, San Antonio, TX 78229, USA
University of Wisconsin Hospital and Clinics ( Site 0037)
600 Highland Ave, Madison, WI 53792, USA
Lyell McEwin Hospital ( Site 1252)
Haydown Rd, Elizabeth Vale SA 5112, Australia
Fakultni Nemocnice Olomouc ( Site 0251)
6, I.P. Pavlova 185, Nová Ulice, 779 00 Olomouc, Czechia
Fakultni Thomayerova nemocnice ( Site 0252)
Vídeňská 800, 140 59 Praha 4-Krč, Czechia
CHU de Brest -Site Hopital Morvan ( Site 0461)
2 Av. Foch, 29200 Brest, France
Institut Universitaire du Cancer Toulouse - Oncopole ( Site 0455)
1 Av. Hubert Curien, 31100 Toulouse, France
Centre Hospitalier Regional du Orleans ( Site 0463)
14 Av. de l'Hôpital, 45100 Orléans, France
Polyclinique du Bois ( Site 0458)
123 Av. de Dunkerque, 59000 Lille, France
Hopital Diaconesses Croix Saint Simon ( Site 0465)
125 Rue d'Avron, 75020 Paris, France
Kath. Krankenhaus Marienhospital. Universitaetsklinik ( Site 0511)
Hölkeskampring 40, 44625 Herne, Germany
Universitaetsklinikum Muenster ( Site 0516)
Albert-Schweitzer-Campus 1, 48149 Münster, Germany
Krankenhaus Martha Maria Halle-Doelau ( Site 0507)
Röntgenstraße 1, 06120 Halle (Saale), Germany
Universitaetsklinikum Carl Gustav Carus ( Site 0509)
Fetscherstraße 74, 01307 Dresden, Germany
Presidio Ospedaliero Santa Maria delle Grazie ( Site 0599)
Via Domitiana, 80078 Località La Schiana, Pozzuoli NA, Italy
AOU San Luigi Gonzaga di Orbassano ( Site 0595)
Regione Gonzole, 10, 10043 Orbassano TO, Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento ( Site 0598)
Piazzale Aristide Stefani, 1, 37126 Verona VR, Italy
Ospedali Riuniti Umberto I GM Lancis G Salesi ( Site 0593)
Ancona, Province of Ancona, Italy
IRCCS Ospedale San Raffaele ( Site 0596)
Via Olgettina, 60, 20132 Milano MI, Italy
Kanazawa University Hospital ( Site 1509)
13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan
Yokohama City University Medical Center ( Site 1508)
Japan, 〒232-0024 神奈川県横浜市南区浦舟町４丁目５７
Kanagawa Cancer Center ( Site 1507)
2-chōme-3-2 Nakao, Asahi Ward, Yokohama, Kanagawa 241-8515, Japan
Tohoku University Hospital ( Site 1503)
1-1 Seiryōmachi, Aoba Ward, Sendai, Miyagi 980-8574, Japan
Gifu University Hospital ( Site 1513)
１番１ Yanagido, Gifu, 501-1194, Japan
Nagasaki University Hospital ( Site 1517)
1-chōme-7-1 Sakamoto, Nagasaki, 852-8102, Japan
Okayama University Hospital ( Site 1516)
2-chōme-5-1 Shikatachō, Kita Ward, Okayama, 700-0914, Japan
Osaka International Cancer Institute ( Site 1514)
3-chōme-1-69 Ōtemae, Chuo Ward, Osaka, 541-8567, Japan
Keio University Hospital ( Site 1504)
Japan, 〒160-8582 東京都新宿区信濃町３５
Toyama University Hospital ( Site 1510)
Toyama University Hospital, 2630 Sugitani, Toyama, 930-0194, Japan
Chonnam National University Hwasun Hospital ( Site 1353)
77 Yongbong-ro, Yongbong-dong, Buk-gu, Kwangju, South Korea
Seoul National University Bundang Hospital ( Site 1355)
South Korea, Gyeonggi-do, Seongnam-si, Bundang-gu, Jeongja-dong, Gumi-ro 173(baekchilsipsam)beo, 82 KR
Asan Medical Center ( Site 1352)
88 Olympic-ro 43-gil, Pungnap 2(i)-dong, Songpa-gu, Seoul, South Korea
Kyungpook National University Chilgok Hospital ( Site 1354)
807 Hoguk-ro, Gugu-dong, Buk-gu, Daegu, South Korea
Gachon University Gil Medical Center ( Site 1356)
21 Namdong-daero 774beon-gil, Guwol-dong, Namdong-gu, Incheon, South Korea
Seoul National University Hospital ( Site 1351)
South Korea, Seoul, Jongno-gu, Daehak-ro, 101 서울대학교암병원
Narodowy Instytut Onkologii ( Site 1051)
Wilhelma Konrada Roentgena 5, 05-077 Warszawa, Poland
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1053)
Monte Cassino 18, 37-700 Przemyśl, Poland
Szpital Wojewodzki im. Mikolaja Kopernika ( Site 1055)
Tytusa Chałubińskiego 7, 75-581 Koszalin, Poland
Altay Regional Oncology Dispensary ( Site 0851)
Barnaul, Altai Krai, Russia, 656045
National Medical Research Radiology Centre ( Site 0869)
Ulitsa Zhukova, 10, Obninsk, Kaluzhskaya oblast', Russia, 249031
National Medical Research Centre of Oncology named after N.N. Blokhin ( Site 0865)
Moscow, Russia, 115478
First Moscow State Medical University n.a. I.M.Sechenov ( Site 0871)
Bol'shaya Pirogovskaya Ulitsa, 2, стр. 4, Moskva, Russia, 119435
St.Petersburg Clinical Hospital RAS ( Site 0864)
University Embankment, 7/9, Sankt-Peterburg, Russia, 199034
St.Petersburg State Medical Univ. n.a. acad. I.P.Pavlov ( Site 0856)
University Embankment, 7/9, Sankt-Peterburg, Russia, 199034
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0852)
Russia, 197758
Sverdlovsk Regional Oncology Hospital ( Site 0867)
Ulitsa Belinskogo, 76, Yekaterinburg, Sverdlovskaya oblast', Russia, 620026
Sverdlovsky Regional Clinical hospital #1 ( Site 0868)
Sverdlovsky, Moscow Oblast, Russia, 141140
Volgograd Regional Uronephrological Center ( Site 0870)
Ulitsa Aleksandrova, 34, Volzhskiy, Volgogradskaya oblast', Russia, 404131
Hospital Universitario Central de Asturias ( Site 0654)
Av. Roma, s/n, 33011 Oviedo, Asturias, Spain
Hospital Germans Trias i Pujol. ICO de Badalona ( Site 0658)
Carretera de Canyet, s/n, 08916 Badalona, Barcelona, Spain
Xarxa Assistencial Universitaria Manresa ( Site 0655)
C/ Dr. Joan Soler, 1-3, 08243 Manresa, Barcelona, Spain
Hospital Universitari de Girona Doctor Josep Trueta ( Site 0653)
Avinguda de França, S/N, 17007 Girona, Spain
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 0660)
Rúa da Choupana, s/n, 15706 Santiago de Compostela, A Coruña, Spain
Hospital Universitario Insular de Gran Canaria ( Site 0657)
Avenida Marítima del Sur, s/n, 35016 Las Palmas de Gran Canaria, Las Palmas, Spain
Hospital Clinico Universitario San Carlos de Madrid ( Site 0651)
Calle del Prof Martín Lagos, s/n, 28040 Madrid, Spain
Hospital Virgen del Rocio ( Site 0659)
Av. Manuel Siurot, S/n, 41013 Sevilla, Spain
MI Clinical oncology dispensary of Dnipropetrovsk regional council ( Site 0954)
Oleksandra Polia Ave, 2, Dnipropetrovs'k, Dnipropetrovs'ka oblast, Ukraine, 49000
Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval ( Site 0952)
Kharkiv, Kharkiv Oblast, Ukraine
Municipal Non-profit Enterprise of Kharkiv Regional Council RCSDRPP ( Site 0965)
Kharkiv, Kharkiv Oblast, Ukraine
Zhytomyr Regional Oncology Center ( Site 0961)
Zhytomyr, Zhytomyr Oblast, Ukraine, 10002
UCLA Hematology/Oncology - Westwood (Building 200 Suite 140)-Department of Urology/Institute of Uro
100 Medical Plaza Driveway Suite 550 & 555, Los Angeles, CA 90095, USA
Gifu University Hospital ( Site 1513)
１番１ Yanagido, Gifu, 501-1194, Japan
Nagoya University Hospital ( Site 1512)
Japan, 〒466-8560 愛知県名古屋市昭和区鶴舞町６５
National Medical Research Centre of Oncology named after N.N. Blokhin ( Site 0865)
Moscow, Russia, 115230
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 0661)
Centro Cellex, Carrer de Natzaret, 115-117, 08035 Barcelona, Spain
Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval ( Site 0952)
Kharkiv, Kharkiv Oblast, Ukraine
St Joseph Heritage Healthcare-Oncology ( Site 0035)
2141 N Harbor Blvd, Fullerton, CA 92835, USA
UF Health ( Site 0031)
1515 SW Archer Rd, Gainesville, FL 32608, USA
University of Louisville, James Graham Brown Cancer Center ( Site 0022)
529 S Jackson St, Louisville, KY 40202, USA
Wake Forest Baptist Health ( Site 0014)
1 Medical Center Blvd, Winston-Salem, NC 27103, USA
Houston Methodist Urology Associates ( Site 0033)
6560 Fannin St Suite 2100, Houston, TX 77030, USA
Mater Hospital Brisbane ( Site 1257)
Raymond Terrace, South Brisbane QLD 4101, Australia
Moncton Hospital ( Site 0107)
135 Macbeath Ave, Moncton, NB E1C 6Z8, Canada
Ottawa Hospital Research Institute ( Site 0109)
501 Smyth Rd, Ottawa, ON K1H 8L6, Canada
Fakultni nemocnice u sv. Anny v Brne ( Site 0253)
Pekařská 664/53, 656 91 Brno-Brno-střed, Czechia
CHU Limoges Hopital Dupuytren ( Site 0459)
16 rue Bernard Descottes, 87042 Limoges, France
Caritas Krankenhaus St. Josef ( Site 0502)
Landshuter Str. 65, 93053 Regensburg, Germany
General Hospital of Athens "Alexandra" ( Site 0303)
Lourou 4-2, Athina 115 28, Greece
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 0301)
Rimini 1, Chaidari 124 62, Greece
University General Hospital of Larissa ( Site 0302)
Tsakalof 1, Larisa 412 21, Greece
Rambam Health Care Campus-Oncology ( Site 0751)
HaAliya HaShniya St 8, Haifa, 3109601, Israel
Rabin Medical Center-Oncology ( Site 0752)
Zeev Jabotinsky St 39, Petah Tikva, 49100, Israel
Sheba Medical Center-ONCOLOGY ( Site 0753)
Derech Sheba 2, Ramat Gan, Israel
Istituto Oncologico Veneto IRCCS-Oncologia Medica 1 ( Site 0600)
Via Gattamelata, 64, 35128 Padova PD, Italy
Hirosaki University Hospital ( Site 1501)
Japan, 〒036-8563 青森県弘前市本町５３
University of Tsukuba Hospital ( Site 1502)
Japan, 〒305-8576 Ibaraki, Tsukuba, Amakubo, 2-chōme−１−１
Hamamatsu University Hospital ( Site 1511)
1-chōme-20-1 Handayama, Higashi Ward, Hamamatsu, Shizuoka 431-3125, Japan
Osaka City University Hospital ( Site 1515)
1-chōme-5-7 Asahimachi, Abeno Ward, Osaka, 545-8586, Japan
Tokyo Medical and Dental University Hospital ( Site 1505)
1-chōme-5-45 Yushima, Bunkyo City, Tokyo 113-8519, Japan
University Malaya Medical Centre ( Site 0352)
Jln Profesor Diraja Ungku Aziz, 59100 Kuala Lumpur, Selangor, Malaysia
Sarawak General Hospital ( Site 0351)
Jalan Hospital, 93586 Kuching, Sarawak, Malaysia
CHLO, EPE - Hospital de Sao Francisco Xavier ( Site 0401)
Estr. Forte do Alto Duque, 1449-005 Lisboa, Portugal
Steve Biko Academic Hospital ( Site 0601)
Steve Biko and, Malan St, Capital Park, Pretoria, 0084, South Africa
Hospital Universitario Central de Asturias ( Site 0654)
Av. Roma, s/n, 33011 Oviedo, Asturias, Spain
I.I. Mechnykov Dnipropetrovsk Regional Clinical Hospital ( Site 0959)
Soborna Square, 14, Dnipropetrovs'k, Dnipropetrovs'ka oblast, Ukraine, 49000
MNPE Regional Center of Oncology ( Site 0955)
Kharkiv, Kharkiv Oblast, Ukraine
Lviv Oncology Regional Treatment and Diagnostic Center ( Site 0960)
Lviv, Lviv Oblast, Ukraine, 79000
Oregon Health and Science University ( Site 0028)
3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
Universitaetsklinikum Freiburg ( Site 0512)
Hugstetter Str. 55, 79106 Freiburg im Breisgau, Germany
Universitaetsklinik fuer Urologie ( Site 0501)
72076 Tübingen, Germany
Hospital Geral de Santo Antonio ( Site 0408)
Hospital de Santo António, 4050 Porto, Portugal
Volga District Medical Center ( Site 0876)
Ulitsa Goncharova, 1Д, Nizhnij Novgorod, Nizhegorodskaya oblast', Russia, 603032
Duke University Medical Center ( Site 0017)
200 Trent Dr, Durham, NC 27710, USA
University of Iowa Hospital and Clinics ( Site 0029)
Iowa City, IA 52242, USA
Fakultni nemocnice u sv. Anny v Brne ( Site 0253)
Brno, Czechia
CHU Jean Minjoz ( Site 0453)
3 Bd Alexandre Fleming, 25000 Besançon, France
Inst. Portugues de Oncologia de Lisboa Francisco Gentil EPE ( Site 0409)
Lisbon, Portugal
Cardiomed SRL Cluj-Napoca ( Site 1101)
Strada Republicii 17, Cluj-Napoca 400015, Romania
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1103)
Strada Republicii 34-36, Cluj-Napoca 400015, Romania
SC Radiotherapy Center Cluj SRL ( Site 1108)
Florești 407280, Romania
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 1107)
Craiova, Romania
Tan Tock Seng Hospital Singapore
Mayo Clinic in Arizona - Phoenix ( Site 0043)
Mayo Clinic, Phoenix, AZ, USA
Stanford University ( Site 0023)
Stanford University, Stanford, CA 94305, USA
University of Colorado, Anschutz Cancer Pavilion ( Site 0009)
13001 E 17th Pl, Aurora, CO 80045, USA
MHAT Central Onco Hospital OOD ( Site 1158)
4000 Plovdiv, Bulgaria
BC Cancer - Vancouver Center ( Site 0110)
Vancouver, BC V5Z 4E6, Canada
Jewish General Hospital ( Site 0106)
3755 Chem. de la Côte-Sainte-Catherine, Montréal, QC H3T 1E2, Canada
SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 1406)
China, Guang Dong Sheng, Guang Zhou Shi, Yue Xiu Qu, 东风东路651号 邮政编码: 510060
Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 1413)
107 Yan Jiang Yi Lu, Yue Xiu Qu, Guang Zhou Shi, Guang Dong Sheng, China, 510123
Hunan Cancer Hospital ( Site 1403)
China, Hu Nan Sheng, Chang Sha Shi, Yue Lu Qu, 582, 湖南省肿瘤医院 邮政编码: 410006
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( S
Nanjing, Jiangsu, China
Nantong Tumor Hospital-Urology ( Site 1405)
68 Gong Nong Lu, Chong Chuan Qu, Nan Tong Shi, Jiang Su Sheng, China, 226007
Fudan University Shanghai Cancer Center-Urology department ( Site 1401)
Shanghai, China
Fakultni nemocnice u sv. Anny v Brne ( Site 0253)
Pekařská 664/53, 656 91 Brno-Brno-střed, Czechia
Fakultni nemocnice Hradec Kralove-Klinika onkologie a radioterapie ( Site 0254)
Sokolská 581, 500 05 Hradec Králové, Czechia
CHU La Timone ( Site 0456)
13005 Marseille, France
Gustave Roussy ( Site 0467)
114 Rue Edouard Vaillant, 94805 Villejuif, France
Hadassah Medical Center-Oncology ( Site 0757)
Kalman Ya'akov Man St, Jerusalem, Israel
Meir Medical Center-oncology ( Site 0754)
Tchernichovsky St 59, Kefar Sava, 4428164, Israel
Sourasky Medical Center-Oncology ( Site 0755)
Dafna St 5, Tel Aviv-Yafo, Israel
Yitzhak Shamir Medical Center-Oncology ( Site 0756)
Be'er Ya'akov, Israel
Nagasaki University Hospital ( Site 1517)
1-chōme-7-1 Sakamoto, Nagasaki, 852-8102, Japan
Okayama University Hospital ( Site 1516)
2-chōme-5-1 Shikatachō, Kita Ward, Okayama, 700-8558, Japan
Osaka Metropolitan University Hospital ( Site 1515)
1-chōme-5-7 Asahimachi, Abeno Ward, Osaka, 545-8586, Japan
Tokyo Medical and Dental University Hospital ( Site 1505)
1-chōme-5-45 Yushima, Bunkyo City, Tokyo 113-8510, Japan
Sunway Medical Centre ( Site 0353)
5, Jalan Lagoon Selatan, Bandar Sunway, 47500 Petaling Jaya, Selangor, Malaysia
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1057)
ul. Poniatowskiego 26, 08-110 Siedlce, Poland
Clinical Research Center Medic-R ( Site 1061)
Poznańska 3, 60-848 Poznań, Poland
Centro Hospitalar e Universitario de Coimbra ( Site 0406)
Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1102)
Strada Republicii 34-36, Cluj-Napoca 400015, Romania
Policlinica Oncomed SRL ( Site 1106)
Timișoara, Romania
SC Focus Lab Plus SRL ( Site 1104)
Strada Cireșului 1, București 024103, Romania
Tan Tock Seng Hospital ( Site 0704)
11 Jln Tan Tock Seng, Singapore 308433
Groote Schuur Hospital ( Site 0602)
Main Rd, Observatory, Cape Town, 7935, South Africa
Hospital Universitari de Girona Doctor Josep Trueta ( Site 0653)
Avinguda de França, S/N, 17007 Girona, Spain
China Medical University Hospital ( Site 1202)
No. 2, Yude Rd, North District, Taichung City, Taiwan 404
Taipei Veterans General Hospital ( Site 1201)
No. 201, Section 2, Shipai Rd, Beitou District, Taipei City, Taiwan 112
University of California San Francisco ( Site 0010)
San Francisco, CA 94158, USA
Indiana University Melvin and Bren Simon Cancer Center ( Site 0050)
535 Barnhill Dr, Indianapolis, IN 46202, USA
Hospital Británico de Buenos Aires-Oncology ( Site 1551)
Perdriel 74, C1280 AEB, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires ( Site 1554)
Buenos Aires, Argentina
Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 1558)
Buenos Aires, Argentina
Fundacion Estudios Clinicos-Oncology ( Site 1557)
Italia 428, S2000DEJ Rosario, Santa Fe, Argentina
Asociación de Beneficencia Hospital Sirio Libanés ( Site 1553)
Campana 4658, C1419 CABA, Argentina
Frankston Hospital-Oncology and Haematology ( Site 1258)
Frankston VIC 3199, Australia
MHAT "Uni Hospital" OOD ( Site 1154)
4500 Panagyurishte, Bulgaria
Complex Oncology Center Plovdiv ( Site 1151)
4000 Plovdiv, Bulgaria
MHAT Serdika ( Site 1152)
Sofia, Bulgaria
Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 1402)
China, Shang Hai Shi, 卢湾区重庆南路280号 邮政编码: 200023
Fundación Colombiana de Cancerología Clínica Vida ( Site 1653)
Av. 33 #63a18, Laureles - Estadio, Medellín, Laureles, Medellín, Antioquia, Colombia
Fundación Cardiovascular de Colombia-Santander ( Site 1657)
Calle 155A No. 23 - 58, Floridablanca, Santander, Colombia
Fundacion Valle del Lili- CIC ( Site 1656)
Cra. 98 #18-49, Cali, Valle del Cauca, Colombia
CHU GRENOBLE ALPES ( Site 0468)
Av. des Maquis du Grésivaudan, 38700 La Tronche, France
Vivantes Klinikum Am Urban ( Site 0519)
Dieffenbachstraße 1, 10967 Berlin, Germany
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 0305)
Rio 265 04, Greece
Athens Medical Center ( Site 0304)
Distomou 5-7, Marousi 151 25, Greece
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ( Site 1010)
Szeged, Hungary
Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház ( Site 1002)
Szolnok, Hungary
Debreceni Egyetem Klinikai Kozpont ( Site 1006)
Debrecen, Nagyerdei krt. 98, 4032 Hungary
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento ( Site 0598)
Piazzale Aristide Stefani, 1, 37126 Verona VR, Italy
Ospedale Cannizzaro ( Site 0590)
Ospedale Cannizzaro, 95126 Catania CT, Italy
Korea University Anam Hospital ( Site 1357)
South Korea, Seoul, Seongbuk-gu, 고려대로 73
Hospital Pulau Pinang ( Site 0355)
Jln. Utama, 10450 George Town, Pulau Pinang, Malaysia
THE MEDICAL CITY ILOILO-The Medical City Iloilo - Clinical and Translational Research Institute-Ilo
Iloilo City, Iloilo, Philippines
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu ( Site 1058)
Borowska 213, 50-556 Wrocław, Poland
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 1107)
Craiova, Romania
Tan Tock Seng Hospital ( Site 0704)
11 Jln Tan Tock Seng, Singapore 308433
Wits Clinical Research ( Site 0603)
Area 477, 7th Floor, Green Block Charlotte Maxeke Johannesburg Academic Hospital, Parktown, Johannesburg, 2193, South Africa
Fundación Instituto Valenciano de Oncología-Oncologico ( Site 0662)
Carrer del Professor Beltrán Báguena, 8, 46009 València, Valencia, Spain
Oncomédica S.A.S ( Site 1652)
Cra. 6 #72-34, Neiva, Montería, Córdoba, Colombia
Institut Català d'Oncologia (ICO) - Girona ( Site 0653)
Sant Ponç, Avinguda de França, 0, 17007 Girona, Spain
Oregon Health and Science University ( Site 0028)
Portland, OR, USA
Hospital Británico de Buenos Aires-Oncology ( Site 1551)
Perdriel 74, C1280 AEB, Buenos Aires, Argentina
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 1654)
Cra. 66 #23 - 46, Teusaquillo, Bogotá, Colombia
Klinički Bolnički Centar Split-Oncology and Radiotherapy ( Site 1702)
Spinčićeva ul. 1, 21000, Split, Croatia
Fakultni Nemocnice Olomouc ( Site 0251)
Zdravotníků 248/7, 779 00 Olomouc, Czechia
Universitaetsklinikum Wuerzburg ( Site 0520)
Josef-Schneider-Straße 2, 97080 Würzburg, Germany
Sheba Medical Center-ONCOLOGY ( Site 0753)
Ramat Gan, Israel
Istituto Oncologico Veneto IRCCS-Oncologia Medica 1 ( Site 0600)
Padua, Province of Padua, Italy
Chang Gung Memorial Hospital at Kaohsiung ( Site 1203)
Kaohsiung, Gushan District, Kaohsiung City, Taiwan
Fundacion Estudios Clinicos-Oncology ( Site 1557)
Rosario, Santa Fe Province, Argentina
Klinički bolnički centar Sestre milosrdnice ( Site 1703)
Vinogradska cesta 29, 10000, Zagreb, Croatia
Gustave Roussy ( Site 0467)
94800 Villejuif, France
Azienda Ospedaliero Universitaria delle Marche-Clinica Oncologica ( Site 0593)
Piazzale Martelli Raffaele, 60121 Ancona AN, Italy
Stanford University ( Site 0023)
Stanford University, Stanford, CA 94305, USA
Centro de Urología (CDU) ( Site 1552)
Av. Córdoba 2424, C1120AAT DF, Argentina
Macquarie University-MQ Health Clinical Trials Unit ( Site 1259)
New South Wales, Australia
CancerCare Manitoba ( Site 0108)
675 McDermot Ave, Winnipeg, MB R3E 0V9, Canada
Klinički bolnički centar Zagreb-Klinika za onkologiju ( Site 1701)
Ulica Mije Kišpatića 12, 10000, Zagreb, Croatia
Klinički bolnički centar Osijek ( Site 1705)
Ul. Josipa Huttlera 4, 31000, Osijek, Croatia
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 1002)
Szolnok, Hungary
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 0588)
Via Giacomo Venezian, 1, 20133 Milano MI, Italy
Kitasato University Hospital ( Site 1506)
1-chōme-15-1 Kitazato, Minami Ward, Sagamihara, Kanagawa 252-0329, Japan
Institutul Oncologic Cluj-Oncologie Medicala ( Site 1109)
Cluj-Napoca, Romania
Altay Regional Oncology Dispensary ( Site 0851)
Prospekt Lenina, 23, Barnaul, Altayskiy kray, Russia, 656049
Torbay Hospital ( Site 1804)
Torbay Hospital, Torquay TQ2 7AA, UK
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 1801)
W Smithfield, London EC1A 7BE, UK
Imperial College Healthcare NHS Foundation Trust - St Mary's Hospital ( Site 1802)
The Bays, S Wharf Rd, London W2 1NY, UK