A Single Arm, Phase Ib/II Trial of Single Agent Pacritinib in Patients With 1q21.3 Amplified Solid Tumors Enriching for Interleukin-1 Receptor-associated Kinase 1 Pathway Activation (PAIR)
Study Start Date
Patients may be included in the study only if they meet all of the following criteria: - Age > or = 21 years. - Histological or cytological diagnosis of malignant advanced solid tumors refractory to standard therapy or for which no suitable effective standard therapy exists. o Patients who fit above criteria will be pre-screened for presence of 1q21.3 amplification using a plasma assay based on digital PCR. Patients with tumors that exhibit 1q21.3amplification will be enrolled. Positive 1q21.3 amplification is defined as more than 3 standard deviations above the mean comparing the averaged copy number ratio of 3 genes (TUFT1, S100A8 and S100A7) relative to the reference gene RPP30 measure in sample (13). - ECOG 0-2 - Has measureable or evaluable disease based on RECIST 1.1 criteria - Estimated life expectancy of at least 12 weeks. - Has documented progressive disease from last line of therapy - Has recovered from acute toxicities from prior anti-cancer therapies - Adequate organ function including the following: - Bone marrow: - Absolute neutrophil (segmented and bands) count (ANC) > or = 1.5 x 109/L - Platelets > or = 100 x 109/L - Hemoglobin > or = 8 x 109/L - Hepatic: - Bilirubin < or = 1.5 x upper limit of normal (ULN), - ALT or AST < or = 2.5x ULN, (or < or = 5 X with liver metastases) - Renal: - Creatinine < or = 1.5x ULN - Signed informed consent from patient - Able to comply with study-related procedures. - Prior therapy (patients enrolled in phase Ib may be enrolled if they fulfil prior therapy criteria for either Cohort A or Cohort B) - Cohort A only: Has received at least 2 lines of systemic therapy (endocrine or chemotherapy) in the palliative setting. Chemotherapy in an adjuvant setting for which patients relapsed within 6 months of completion can be considered as line(s) of palliative therapy. - Cohort B only: Any number of prior lines of palliative chemotherapy.